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In a 2018 research paper, Dr. Elena Rodriguez examined the scientific community's initial response to CRISPR gene-editing technology. Rodriguez noted...

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In a 2018 research paper, Dr. Elena Rodriguez examined the scientific community's initial response to CRISPR gene-editing technology. Rodriguez noted that many senior researchers questioned the technique's long-term safety. This concern can be seen when Dr. Patricia Williams states, _____

Which quotation from Dr. Patricia Williams most effectively illustrates the concern described in the text?

A

"CRISPR represents a significant advancement in molecular biology, with applications spanning from agriculture to medicine. The technique has generated considerable interest across multiple disciplines."

B

"While CRISPR shows remarkable precision, I remain deeply troubled by the possibility of unintended genetic consequences that we may not discover for decades. We simply cannot predict all the ramifications of such powerful interventions."

C

"Dr. Jennifer Doudna and Dr. Emmanuelle Charpentier shared the 2020 Nobel Prize in Chemistry for developing the CRISPR-Cas9 genetic scissors. Their work has opened new possibilities in genetic research."

D

"CRISPR technology has been successfully used in clinical trials for treating sickle cell disease. Several patients have shown significant improvement following treatment with CRISPR-modified cells."

Solution

Step 1: Decode and Map the Passage

Create Passage Analysis Table

Text from PassageAnalysis
"In a 2018 research paper, Dr. Elena Rodriguez examined the scientific community's initial response to CRISPR gene-editing technology."
  • What it says: Rodriguez studied sci community's first reactions to CRISPR (2018)
  • What it does: Introduces the research study and its focus
  • What it is: Research context
"Rodriguez noted that many senior researchers questioned the technique's long-term safety."
  • What it says: Senior researchers worried about CRISPR safety over time
  • What it does: Presents the key finding from Rodriguez's study
  • What it is: Main research finding
"This concern can be seen when Dr. Patricia Williams states, ______"
  • What it says: Williams' quote will show this safety concern
  • What it does: Sets up evidence for the concern just mentioned
  • What it is: Evidence setup

Provide Passage Architecture & Core Elements

Main Point: Rodriguez's research found that senior researchers had concerns about CRISPR's long-term safety, which can be illustrated through Dr. Williams' statements.

Step 2: Interpret the Question Precisely

This is a fill-in-the-blank question asking us to choose the best logical connector. The answer must create the right relationship between what comes before and after the blank.

Step 3: Prethink the Answer

  • The correct answer must express concern or worry about CRISPR's long-term safety
  • We're looking for language that suggests uncertainty about future consequences or potential problems that might emerge over time
Answer Choices Explained
A

"CRISPR represents a significant advancement in molecular biology, with applications spanning from agriculture to medicine. The technique has generated considerable interest across multiple disciplines."

✗ Incorrect

  • Shows CRISPR positively as advancement - no safety concerns expressed
B

"While CRISPR shows remarkable precision, I remain deeply troubled by the possibility of unintended genetic consequences that we may not discover for decades. We simply cannot predict all the ramifications of such powerful interventions."

✓ Correct

  • Explicitly expresses being troubled by possibility of unintended genetic consequences that may not be discovered for decades - matches the long-term safety concern perfectly
C

"Dr. Jennifer Doudna and Dr. Emmanuelle Charpentier shared the 2020 Nobel Prize in Chemistry for developing the CRISPR-Cas9 genetic scissors. Their work has opened new possibilities in genetic research."

✗ Incorrect

  • States factual information about Nobel Prize - no concern expressed
D

"CRISPR technology has been successfully used in clinical trials for treating sickle cell disease. Several patients have shown significant improvement following treatment with CRISPR-modified cells."

✗ Incorrect

  • Presents CRISPR positively through successful trials - shows confidence rather than concern
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